The landscape of substance use on college campuses is broadening. In an effort for prevention strategies to reflect this changing landscape, a recent study aimed to determine if distinct profiles existed among college students that used marijuana or alternative forms of tobacco, engaged in extreme heavy episodic drinking (HED), or misused prescription drugs. In addition, the study examined if demographic, academic, or social activities served as predictors for these said profiles. This study included fourth-year undergraduate participants already enrolled in a web-based longitudinal study at a specific university. Participants (n=608) completed an online survey where they were asked to self-report extreme HED, marijuana use, hookah use or prescription drug misuse in the past year, as well as cigarette use, cigar use or smokeless tobacco use in the past month. Participants also self-reported involvement in a variety of academic and social activities. Latent class analysis predicted five patterns of substance use behavior, including: 1. Non/Low Users (61.8% of sample); 2. Hookah & Marijuana Users (12.9%); 3. Extreme HED & Marijuana Users (12%); 4. Non-Hookah Tobacco Users (6.8%); and, 5. Poly-Substance Users (5.6%). Further analysis identified social and academic predictors for some classes. For example, sports-involved students were more likely in the ‘Non-Hookah Tobacco’ or ‘Poly-Substance’ User classes, students involved in Greek organizations were more likely in the ‘HED & Marijuana’ or ‘Poly-Substance’ User classes, and students in honor societies were more likely in the ‘Hookah & Marijuana’ User class (all compared to participants in the Non/Low Users class). Take Away: The heterogeneity of substance use among college students in this study suggests that prevention and intervention efforts must reflect this new breadth, with perhaps tailored efforts towards specific populations of substance users or students involved in specific social or academic activities.