Previous research has established that experiencing health anxiety, or the excessive worry about one’s health, is associated with the use of alcohol and illicit drugs—but what about the misuse of prescription drugs? To address this question, a recent study asked college students enrolled in a psychology class at a large urban university to complete several online instruments assessing their health anxiety, misuse of prescription drugs, as well as other health items. In this study, 29.7% of participants self-reported prescription drug misuse within their lifetime, and logistic regression analysis predicted that high health anxiety served as a significant risk factor for prescription drug misuse. Moreover, participants experiencing chronic health conditions were significantly more likely to misuse prescription drugs than those not experiencing a chronic health condition (35.6% v. 27.2%, respectively). Take Away: Although this study does not establish causality, it is well known that behaviors such as self-diagnosing and self-prescribing contribute toward prescription drug misuse. This study suggests experiencing high health anxiety may fuel these self-medicating behaviors. Moreover, it suggests our prevention efforts should expand to include our university student health centers, ensuring we take a proactive approach toward preventing prescription drug misuse.