Opioid drug misuse is on the rise, partly fueled by individuals misusing prescription opioid pain medications, as well as those transitioning from prescription opioids to heroin. In order to implement successful opioid prevention and recovery efforts, a recent study aimed to re-assess the demographic landscape of opioid users. Using data collected from the 2010-2013 National Survey on Drug Use and Health, this study correlated demographics, such as socioeconomics and health characteristics, for three groups of opioid users: those only misusing prescription opioid pain medications (PP-O; n=9,516), those only using heroin (H-O; n=179), and those concurrently using both drugs (H-PP; n=506). Between the PP-O and H-PP groups, the authors identified two primary differences in demographics: 1) PP-O misusers were the most connected to social institutions (e.g., family, work, religion), while H-O users were the least socially connected; and 2) H-PP users experienced the worst health outcomes, with higher reports of mental health problems. Moreover, data revealed H-PP users reported more episodes of polysubstance use, indicating concurrent use of different opioids may trigger a larger substance misuse problem. Take-Away: As we develop and implement prevention and recovery efforts for misuse of prescription opioid pain medications, consider developing unique approaches to best fit the characteristics of the opioid user. Based on the combination of opioids used, a “one size fits all” approach may not be effective.