Previous studies have assessed the prevalence of prescription drug misuse among undergraduate students, but what about professional students? A recent study evaluated the prevalence of illicit drug, alcohol, and tobacco use, as well as prescription drug misuse among healthcare professional students. Consenting students attending pharmacy, medicine, or physician assistant (PA) schools/programs in California were invited to complete a web-based survey that measured self-reported use of alcohol, tobacco, and illicit drugs, as well as the misuse of prescription drugs (n=589 participants; 309 pharmacy, 173 medicine, 107 PA students). Past year prevalence of alcohol and tobacco use were similar across the three groups of professional students, yet medical students reported a statistically higher prevalence of marijuana use (20.8%) compared to pharmacy (7.4%) or PA (8.4%) students. In addition, both medical (10.4%) and PA (14.0%) students reported a statistically higher prevalence of past-year prescription stimulant misuse than pharmacy students (6.1%). Altogether, over half of respondents (52%) reported obtaining prescription stimulants from a friend/classmate, and “to improve concentration/help me focus” remained the most frequent reported reason for misuse. Lastly, frequency of prescription stimulant misuse varied among respondents—from daily use (13.5%), to use 2-3X per month (9.6%), to use only during examination periods (11.5%). Take Away: Professional students remain an integral part of any campus community—we should ensure that our prevention and recovery efforts also support this population. In addition, with the challenges and pressures associated with rigorous graduate programs, prevention efforts that target prescription stimulant misuse may consider also teaching professional students healthy study habits.