Twitter remains a popular platform to communicate information, including misperceptions about prescription drugs. To gain insight into how individuals perceive or describe prescription opioid pain medications, a recent study analyzed tweets posted over the course of 10 days that included key terms related to these medications (i.e. Percocet, Percs, OxyContin, Oxys, Vicodin, and Hydros). Three investigators collectively analyzed 2,100 tweets containing one or more of these key terms, and categorized each tweet as either “abuse” (i.e. used to get high), “not abuse” (i.e. used therapeutically or misused), or “not characterizable”. Tweets were further characterized as “positive” (i.e. individual would use again), “negative” (i.e. individual experienced an adverse event and would not use again), or “not characterizable”. Depending on the keyword, between 37.5 – 65% of tweets were categorized as “abuse”, with over 66% of all tweets characterized as “positive”. This study did not consider misuse as a form of abuse, and thus did not distinguish amongst the behaviors that defined “not abuse”. Take-Away: Although social media provides an additional platform for some individuals to normalize the misuse of prescription drugs, we also have an opportunity to flip the conversation. Shifting the social media conversation to education and awareness helps combat the misperceptions that fuel prescription drug misuse as well as provide an engaging platform to discuss this issue with young adults.